1.
Bioorg Med Chem Lett
; 12(3): 441-6, 2002 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11814816
RESUMO
Synthesis and SARs of new integrin alpha(V)beta(3) antagonists based on an N-substituted dibenzazepinone scaffold are described. Variation of spacer and guanidine mimetic led to potent compounds exhibiting an IC(50) towards alpha(V)beta(3) in the nanomolar range, high selectivity versus integrin alpha(IIb)beta(3) and efficacy in functional cellular assays.